GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs10444533 | 1 | rs11113118 | chr12:107199142 | MTERFD3 | chr12:107371069-107380929:- | -0.14 | -4.09 | 4.55E-5 | Social autistic-like traits |
| BRCA | cis | rs12579753 | 1 | rs11115047 | chr12:82232773 | PPFIA2 | chr12:81652880-82153109:- | 0.14 | 3.48 | 0.000522 | Resting heart rate |
| BRCA | cis | rs4908760 | 1 | rs11121201 | chr1:8632791 | RERE | chr1:8412466-8877699:- | 0.11 | 3.53 | 0.00044 | Vitiligo |
| BRCA | cis | rs4925540 | 1 | rs1112137 | chr1:247215375 | ZNF670 | chr1:247200087-247242069:- | -0.25 | -6.98 | 5.08E-12 | Response to taxane treatment (docetaxel) |
| BRCA | cis | rs17401966 | 1 | rs11121533 | chr1:10292888 | PGD | chr1:10459085-10480200:+ | 0.19 | 5.55 | 3.59E-8 | Hepatocellular carcinoma |
| BRCA | cis | rs17401966 | 1 | rs11121552 | chr1:10435324 | PGD | chr1:10459085-10480200:+ | 0.23 | 6.34 | 3.31E-10 | Hepatocellular carcinoma |
| BRCA | cis | rs11123170 | 1 | rs11123170 | chr2:113978940 | LOC654433 | chr2:113993107-114024579:+ | -0.79 | -21.3 | 3.7E-84 | Renal function-related traits (BUN) |
| BRCA | cis | rs11123170 | 1 | rs11123170 | chr2:113978940 | PAX8 | chr2:113973575-114036498:- | -0.66 | -16.85 | 1.08E-56 | Renal function-related traits (BUN) |
| BRCA | cis | rs111803315 | 1 | rs111237243 | chr14:59991030 | C14orf149 | chr14:59939406-59951126:- | -0.26 | -3.8 | 0.000153 | Schizophrenia |
| BRCA | cis | rs111803315 | 1 | rs111237243 | chr14:59991030 | JKAMP | chr14:59951161-59972080:+ | 0.32 | 5.6 | 2.76E-8 | Schizophrenia |
| BRCA | cis | rs1853207 | 1 | rs111237645 | chr10:96462701 | C10orf129 | chr10:96953957-96988685:+ | 0.33 | 5.44 | 6.55E-8 | Blood metabolite levels |
| BRCA | cis | rs2041840 | 1 | rs11124575 | chr2:37500435 | CEBPZ | chr2:37428778-37458740:- | -0.17 | -5.21 | 2.33E-7 | Chronic lymphocytic leukemia |
| BRCA | cis | rs12468226 | 1 | rs111252524 | chr2:203199188 | NOP58 | chr2:203130515-203168382:+ | 0.15 | 3.41 | 0.000665 | Urate levels |
| BRCA | cis | rs11125529 | 1 | rs11125529 | chr2:54475866 | C2orf73 | chr2:54558071-54588714:+ | -0.17 | -4.27 | 2.15E-5 | Telomere length |
| BRCA | cis | rs4671458 | 1 | rs11125949 | chr2:63357876 | C2orf86 | chr2:63348537-63815851:- | -0.22 | -5.4 | 8.32E-8 | Subjective well-being |